Talk:Antidepressant
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Clarified initial paragraph about efficacy[edit]
I changed the last few sentences in the opening paragraph to clarify that the debate about antidepressant efficacy is about how much of the observed effect is due to placebo, not if all observed effects is due to placebo.I added an additional reference to that claim compared with what was already there. I also added in a sentence with six references that clarifies that the bulk of the scientific research shows that the efficacy of antidepressants is superior to placebo, as the initial paragraph had a clear anti-psychiatry bias since the only reference on efficacy was a review paper by Irving Kirsch (noted opponent to antidepressants), no primary research papers and no balanced treatment of the issue. EmilKarlsson (talk) 18:28, 3 August 2019 (UTC)
Antidepressant withdrawal symptoms[edit]
This seems relevant for the section on discontinuation syndrome:
A new systematic review reports that about half of the patients discontinuing anti-depressants experience withdrawal symptoms. About half of those who experiencing withdrawal symptoms consider them severe.
<redact likely WP:COPYLINK violation>
http://prescribeddrug.org/millions-at-risk-from-antidepressant-withdrawal-new-review-concludes/
While most data is on SSRI/SNRI, the review also includes some studies on tricyclics and MAOIs. Another question that this review raises is whether 'discontinuation syndrome' should actually be replaced by 'withdrawal'. The article argues in favour of the latter on the basis of incidence, severity and duration of the withdrawal effects.Lucleon (talk) 20:03, 2 October 2018 (UTC)
- I've removed what appears to be a WP:COPYLINK violation. See also here - the paper has been temporarily retracted for some reason. (prior link is archiveurl for today; here is the live sciencedirect link, which may change) Jytdog (talk) 20:12, 2 October 2018 (UTC)
The paper is online now: https://www.sciencedirect.com/science/article/abs/pii/S0306460318308347 including the following main claims:
"-More than half (56%) of people who attempt to come off antidepressants experience withdrawal effects.
-Nearly half (46%) of people experiencing withdrawal effects describe them as severe.
-It is not uncommon for the withdrawal effects to last for several weeks or months. ". I'd be happy to draft a short summary if this considered sufficient support for including it in the section discontinuation syndrome here and probably as well in the respective section for SSRI. Lucleon (talk) 12:49, 3 October 2018 (UTC)
- @Lucleon: I would be happy to see that summary if you are still interested in writing it. I know that many object to the term "discontinuation syndrome" on the basis that it is just a euphemism for withdraw. This viewpoint deserves to be heard.
- I've added this information a while a go to Antidepressant discontinuation syndrome Lucleon (talk) 09:15, 4 May 2019 (UTC)
Content[edit]
It seems quite a bit of good content was removed. Benjamin (talk) 12:10, 28 April 2019 (UTC)
- yes, and that doesn't make the article better. for example, the section effectiveness still describes the more than a decade old star*d trial in complete detail while the most comprehensive systematic review from 2018 and other systematic reviews from the last years have been removed.Lucleon (talk) 16:47, 1 May 2019 (UTC)
- An encyclopedia should first be readable and second verifiable. We should strive for summaries rather than complete detail. I agree that most of the STAR*D section should be deleted. Wikiman2718 (talk) 23:45, 1 May 2019 (UTC)
- I'd rank verifiability over readability, at leat readable but not verifiable seems problematic to me, but anyway I agree that the section on effectiveness can be improved, so let's try to do that.Lucleon (talk) 21:22, 2 May 2019 (UTC)
- @Lucleon: Great. I'll try to add in some of those studies from earlier as time allows. I plan to clear out a lot more material in the future. If I delete something you think is important, just leave me a message about it.
- I'd rank verifiability over readability, at leat readable but not verifiable seems problematic to me, but anyway I agree that the section on effectiveness can be improved, so let's try to do that.Lucleon (talk) 21:22, 2 May 2019 (UTC)
- An encyclopedia should first be readable and second verifiable. We should strive for summaries rather than complete detail. I agree that most of the STAR*D section should be deleted. Wikiman2718 (talk) 23:45, 1 May 2019 (UTC)
Cognitive performance and SSRIs[edit]
Serotonin is an inhibitory neurotransmitter and thus, has been using to calm down hypersensitive lymbic systems of patients with depression and anxiety disorders. However, due to its inhibitory function, the serotonin may also supresses the function of dopamine, a neurotransmitter that affects memory and learning in a positive way. There are some studies confirming SSRIs' adverse effects on cognitive functions. There are also studies arguing the vica versa. As far as I can see, the article has no info regarding SSRIs-cognitive functions/performance connection. I can create a subsection discussing the connection, but I am not sure if this would be UNDUE. Puduḫepa (talk) 08:25, 22 June 2019 (UTC)
- Serotonin can have excitatory or inhibitory effects depending on the postsynaptic receptor type. For example, the 5-HT1 receptor is inhibitory while 5-HT2 is excitatory. There is no simple relationship between serotonin and dopamine. Having said that substantial results on cognitive function during SSRI treatment would of course be interesting.Lucleon (talk) 10:05, 22 June 2019 (UTC)
- I don't know how it should be phrased, but it seems like it's worth at least a mention. Benjamin (talk) 10:20, 26 June 2019 (UTC)
Eating disorders[edit]
would adding the cochrane common mental disorder's systematic review on treatment of anorexia nervosa with antidepressants [1] be useful? Edieg02 (talk) 13:55, 10 July 2019 (UTC)
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